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This is a Animal Study study (also classified as: Experimental Study).

October 2, 2025Open Access

Supplementary figure 7 from Nrf2 Hyperactivation as a Driver of Radiotherapy Resistance and Suppressed Antitumor Immunity in Head and Neck Squamous Cell Carcinoma

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Nrf2 knockdown in Keap1-deficient HNSCC cell lines increased radiotherapy sensitivity, highlighting its role in resistance.
The study observed a notable reduction in tumor growth when nrf2 was targeted, suggesting a link to antitumor immunity.
Experimental analysis focused on cell response to radiotherapy in genetically modified murine models, revealing key insights.
Findings support the potential for targeting nrf2 to enhance radiotherapy outcomes in head and neck cancer treatment.

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Knockdown of nrf2 reduced radiotherapy resistance in keap1-deficient HNSCC cell lines, indicating a role in antitumor immunity.

Nrf2 knockdown in Keap1-deficient murine HNSCC cell lines and RT responses

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Patel et al. (2025) studied this question.

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Knockdown of nrf2 reduced radiotherapy resistance in keap1-deficient HNSCC cell lines, indicating a role in antitumor immunity.

Nrf2 knockdown in Keap1-deficient murine HNSCC cell lines and RT responses