Therapeutic Potential and Mechanisms of Curcumin in Cardiovascular Diseases: A Comprehensive Review

ABSTRACT Background Curcumin is recognized for its therapeutic potential in cardiovascular diseases (CVDs), with effects on cardiomyocytes, vascular function, and hypertrophy. Objective This review aims to evaluate curcumin's therapeutic effects, mechanisms of action, and safety in CVD management. Methods A comprehensive review of existing literature was conducted, focusing on curcumin's impact on ischemia, hypoxia, myocardial hypertrophy, fibrosis, and endothelial function. Results Curcumin protects cardiomyocytes, enhances vascular function, and exhibits inconsistent effects on cholesterol accumulation in macrophages. Conclusion While curcumin shows promise as a complementary agent in CVD management, further research, particularly large‐scale clinical trials, is essential to validate its efficacy and safety.