Strategic targeting of mitochondria in ischemic heart disease: mechanisms and emerging therapies.

Key Points

• This research aims to explore targeted therapies for mitochondrial injury in ischemic heart disease (IHD).
• Analyzed mechanisms of mitochondrial injury and adaptive failure in IHD.
• Reviewed strategies for biomarker-guided patient stratification.
• Evaluated optimized systems for drug delivery.
• Discussed design considerations for clinical trials.
• Identified key therapeutic window stages for effective intervention.
• Highlighted the necessity of biomarker-guided treatment strategies.
• Showed potential for improved clinical outcomes through optimized delivery systems.