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Research Paper | Synapse

March 5, 2026Open Access

Diagnostic and prognostic role of maternal serum prokineticin-1 in preeclampsia and adverse pregnancy outcomes

Key Points

This research aims to evaluate the role of maternal serum prokineticin-1 as a diagnostic and prognostic marker in preeclampsia.
Examined levels of maternal serum PROK-1 in pregnancies with preeclampsia
Coronelated PROK-1 levels with disease severity and perinatal outcomes
Compared PROK-1 with existing angiogenic biomarkers.
Elevated PROK-1 levels were observed in women with preeclampsia
The severity of preeclampsia correlated with higher PROK-1 levels
PROK-1 may enhance the predictive accuracy of multimarker models for adverse pregnancy outcomes.

Abstract

Maternal serum PROK-1 was elevated in PE and correlated with disease severity and adverse perinatal outcomes. Although inadequate as a stand-alone marker, PROK-1 may complement existing angiogenic biomarkers in multimarker prediction models.

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Authors

M

Merve Ayas Özkan

Zübeyde Hanim Maternity Hospital

A

Aziz Kından

Sağlık Bilimleri Üniversitesi

İ

İslam Aslanlı

University of Health Science

Journals

Journal of the Turkish-German Gynecological Association

Actions

Institutions

Sağlık Bilimleri Üniversitesi

University of Health Science

University of Health Sciences Antigua

References and Citations

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Cite this study

Özkan et al. (Tue,) studied this question.

synapsesocial.com/papers/69a91e02d6127c7a504c18ae — DOI: https://doi.org/10.4274/jtgga.galenos.2026.2025-10-12