Anshen Jieyu Decoction: A Promising Remedy for Depression via AKT/mTOR Pathway Modulation in CUMS Rats

Key Points

• This research investigates the effects of Anshen Jieyu Decoction on depression and its underlying mechanisms in a rat model of chronic stress.
• Utilized CUMS (chronic unpredictable mild stress) model in rats to induce depression-like behavior.
• Administered Anshen Jieyu Decoction to evaluate its effects on behavioral deficits.
• Assessed biochemical markers including AKT and mTOR phosphorylation and HPA axis activity.
• Anshen Jieyu Decoction improved behavioral deficits in CUMS-induced rats.
• Treatment reduced hyperactivity of the hypothalamic-pituitary-adrenal axis.
• Increased phosphorylation of AKT and mTOR was observed, indicating pathway activation.
• Neuronal damage in hippocampus was significantly reduced.