Supplemental Figure S3 from Collagen XVII Promotes Pancreatic Ductal Adenocarcinoma Tumor Growth through Regulation of PIK3R5

Key Points

• Collagen XVII promotes tumor growth in pancreatic ductal adenocarcinoma, enhancing proliferation and survival.
• Key evidence indicates regulation of PIK3R5 in the tumor microenvironment by collagen XVII.
• Assessment through immunohistochemical and histologic analysis elucidated tumor characteristics in COLXVII-deficient cells.
• Findings support further exploration of collagen roles in PDAC, highlighting potential therapeutic approaches.