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May 30, 2026Journal of Clinical Oncology

Sepsis-related mortality in adults with liver and intrahepatic bile duct malignancies: A 25-year national analysis of trends and disparities, 1999-2023.

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Authors

BKBhaskar KambhampatiLPLeela Lakshmi Sai Srinivas ParasaPVPranav Vempati

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Overview

Analysis quantifies sepsis-related mortality trends among adults with liver malignancy, highlighting disparities and urgent intervention needs.

Key Points

  • The study aims to quantify trends in sepsis-related mortality among adults with liver malignancy and identify demographic and geographic disparities.
  • Analyzed CDC WONDER database data from 1999–2023 for adult deaths with co-occurring ICD-10 codes for sepsis and liver malignancy.
  • Extracted age-adjusted mortality rates (AAMR) per 1,000,000 population.
  • Used Joinpoint regression to assess temporal trends and calculate annual percent change (APC) and average annual percent change (AAPC).
  • 24,924 sepsis-related deaths recorded from 1999 to 2023, with overall mean AAMR increasing from 2.41 to 6.85 (AAPC: 5.10%, 95% CI: 4.83-5.36).
  • Males had higher mortality rates (5.72) than females (2.72), both showing significant increases over the years.
  • Highest AAMRs were observed among Non-Hispanic Asian or Pacific Islanders (8.88) and adults aged ≥65 years, with crude mortality rates up from 7.85 in 1999 to 22.40 in 2023.

Cite This Study

Kambhampati et al. (2026) studied this question.

synapsesocial.com/papers/6a1a7f990307b78509431d79https://doi.org/10.1200/jco.2026.44.16_suppl.e16204
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Trends in Sepsis-Related Mortality among Individuals with Liver Disease in the United States: 1999–20202025
  2. 2National trends in sepsis-related mortality among decedents with malignant neoplasms in the United States, 1999–2023.2026
  3. 3Trends and disparities in sepsis-related mortality among patients with lung cancer: A 25-year nationwide analysis.2026
  4. 4Sociodemographic disparities in sepsis-associated mortality among patients with gastrointestinal malignancies in the United States, 1999-2020.2026
  5. 5Trends in sepsis-related mortality among adults with cancer aged ≥ 25 years in United States, 1999-2020: A CDC WONDER study.2026