Table S8 from RGN6024 Is a Brain-Penetrant, Small-Molecule Tubulin Destabilizer for the Treatment of Glioblastoma

Key Points

• MAIN FINDING: RGN6024 shows effective brain penetration as a tubulin destabilizer for glioblastoma treatment.
• KEY EVIDENCE: It achieves substantial plasma and tumor levels in LN-18 xenograft mouse models, enhancing efficacy.
• APPROACH: The research utilizes a subcutaneous LN-18 xenograft mouse model to assess RGN6024's pharmacokinetics.
• SIGNIFICANCE: These findings indicate RGN6024 may provide a new therapeutic option for glioblastoma patients.