Table S7 from RGN6024 Is a Brain-Penetrant, Small-Molecule Tubulin Destabilizer for the Treatment of Glioblastoma

Key Points

• MAIN FINDING: RGN6024 acts as a tubulin destabilizer, showing potential for treating glioblastoma effectively.
• KEY EVIDENCE: Pharmacokinetic parameters in mice confirm robust brain penetration and favorable distribution.
• APPROACH: The study involved administering RGN6024 to model mice and measuring its pharmacokinetic effects.
• SIGNIFICANCE: RGN6024's brain-penetrant properties suggest enhanced therapeutic options for glioblastoma patients.