Figure S18 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer

Key Points

• Inhibition of mTOR initiates ferritinophagy and ferroptosis in head and neck cancer cells, potentially aiding treatment strategies.
• Ferrostatin-1 reduces the impact of mTOR inhibitors and auranofin by diminishing ferroptosis in vivo, hinting at therapeutic potential.
• The research utilized genome-wide CRISPR screening to uncover these cellular mechanisms behind cancer progression and treatment.
• Understanding how mTOR inhibition influences ferroptosis highlights new directions in cancer care and requires further exploration.