Figure S20 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Key Points

• Murine B7-H3 CAR T cells effectively reduce tumor cells in vitro, demonstrating significant potential against ependymomas.
• Evidence shows murine B7-H3 CAR T cells have efficacy against murine ZFTA-RELA EPN, indicating a promising treatment path.
• In vitro assessment of B7-H3 CAR T cells against ependymomas highlights limitations due to tumor size and immune response.
• Findings underscore the need for strategies to enhance CAR T cell effectiveness against larger tumors and immune barriers.