Figure S11 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Key Points

• B7-H3 CAR T cells are effective against ependymomas, but their efficacy is limited by tumor size and the immune response.
• The analysis of human HER2.CAR T-cells reveals critical phenotypic characteristics relevant to their targeting capabilities.
• Observational analysis on the role of tumor size and immune response is essential for understanding CAR T cell efficacy.
• Understanding the limitations of immune response can guide potential improvements in CAR T cell therapies against ependymomas.