Supplementary Figure S3 from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity

Key Points

• Inhibiting mitophagy improves antitumor immunity in aging T-cells, suggesting critical interactions in immune functions.
• Aβ40 is sufficient but not necessary to inhibit mitophagy, highlighting distinct roles of amyloid-beta peptides.
• The study employs analysis of aging T-cells to assess the effects of amyloid-β on mitophagy and immunity.
• This research may inform future strategies for enhancing antitumor responses, especially in aging populations.