A single high-intensity interval training session increased medium-molecular-weight adiponectin by approximately 19% in inactive young adults (p < 0.05).
Does a single high-intensity interval training (HIIT) session acutely alter circulating adiponectin isoforms and metabolic markers in physically inactive young adults?
A single session of high-intensity interval training acutely increases medium-molecular-weight adiponectin in physically inactive young adults, suggesting a rapid and favorable metabolic response to acute exercise.
Absolute Event Rate: 0% vs 0%
Abstract Background Physical inactivity is a key risk factor for metabolic disorders. High-intensity interval training (HIIT) has been recognized for its metabolic benefits, but its acute effects on adiponectin isoforms remain unclear. This study examines the impact of a single HIIT session on circulating adiponectin (high-molecular weight; HMW, medium-molecular-weight; MMW, and low-molecular weight; LMW) isoforms and metabolic outcomes in insufficiently active young adults. Methods A quasi-experimental study was conducted with 21 physically inactive adults (11 women, 10 men, mean age 22.7 ± 1.5 years). Participants performed a HIIT session consisting of six bouts at 80% heart rate reserve (HRR). Pre- and post-exercise blood samples were ana-lyzed for adiponectin isoforms via Western blotting, and metabolic markers were assessed. Statistical analyses included Wilcoxon tests. Results MMW adiponectin significantly increased (~ 19%; effect size 95%CI: 0.49 -0.02-1.00 p < 0.05), while LMW and HMW adiponectin remained unchanged. The HMW/MMW ratio decreased (-16%; effect size 95%CI: -0.49 -0.99-0.00 p < 0.05). Additionally, non-HDL cholesterol (effect size 95%CI: 0.464 -0.03-0.958) and lactate levels (effect size 95%CI: 1.164 0.568–1.759) increased post-exercise (both p < 0.05). Conclusions A single HIIT session acutely increases MMW adiponectin in insufficiently active young adults. Further research is needed to determine the long-term metabolic implications of repeated HIIT sessions on adiponectin isoform dynamics. Trial registration retrospectively registered in ClinicalTrials.gov (NCT07146867) on August 21st, 2025.
Alvarado-Carrasco et al. (Tue,) reported a other. A single high-intensity interval training session increased medium-molecular-weight adiponectin by approximately 19% in inactive young adults (p < 0.05).