A decrease in base excess, indicating acidosis, was significantly correlated with elevated Gensini scores in patients with coronary artery disease (β: -0.04, P=0.027).
Is peripheral blood base excess associated with the severity of coronary artery disease in patients undergoing coronary angiography?
Lower base excess (tending toward acidosis) is significantly associated with greater severity of coronary artery disease as measured by the Gensini score.
Absolute Event Rate: 0% vs 0%
Introduction: Base excess (BE) is an indicator of non-respiratory acid-base imbalances, which can impact coronary artery disease (CAD). This study evaluated the association between the severity of CAD and peripheral blood BE. Methods: This cross-sectional study included patients aged 18 and older who were candidates for coronary angiography. Demographic and clinical data were collected from medical records. Blood gas analysis was performed on a 2-millilitre arterial blood sample taken from the access artery before contrast injection. All patients underwent coronary angiography, and the Gensini score was calculated. Results: A total of 351 patients (194 males, 55.3%) were included in the study. The study population had a mean age of 60.79±9.5 and a mean BMI of 29.4±4.85. Coronary angiography revealed normal or minimal (<50% stenosis) findings in 51.3% of cases (15.4% with normal coronary arteries and 35.9% with minimal non-obstructive lesions), single-vessel disease in 17.4%, two-vessel disease in 14.5%, and three-vessel disease in 16.8%. Median Gensini score was 13.0, with an IQR of 3.5 and 49. The findings indicated that a decrease in BE was significantly correlated with elevated Gensini scores (β: -0.04; 95% CI: -0.08 to -0.01; P=0.027). However, BE did not significantly affect the Gensini score of 0 (P=0.843). Moreover, negative values of BE were significantly and inversely associated with the Gensini score (β=-0.05; 95% CI: -0.07 to -0.02, P<0.001). Conclusion: This study revealed an association between BE and CAD, suggesting that BE tending to acidosis is potentially associated with CAD.
Amirzadegan et al. (Wed,) reported a other. A decrease in base excess, indicating acidosis, was significantly correlated with elevated Gensini scores in patients with coronary artery disease (β: -0.04, P=0.027).
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