Ir-catalyzed asymmetric transfer hydrogenation of racemic quinolinyl-substituted tertiary alcohols

Key Points

• The goal is to develop an efficient method for producing chiral tetrahydroquinolines from racemic precursors using Ir-catalysis.
• Employing Ir-catalyzed reactions
• Utilizing racemic quinolinyl-substituted tertiary alcohols
• Targeting stereodivergence to produce both endo- and exocyclic chiral products
• Successfully generated structurally unique chiral 1,2,3,4-tetrahydroquinolines
• Demonstrated high efficiency in the stereodivergent transformation
• Showed versatility in generating different chiral centers