Impact of carbon-ion radiotherapy on tumor hypoxia detected by 18F-FMISO PET/CT in locally advanced non-small cell lung cancer

Key Points

• This research aims to investigate the effects of carbon-ion radiotherapy on tumor hypoxia in patients with locally advanced non-small cell lung cancer.
• Utilized 18F-FMISO PET/CT to measure tumor hypoxia before and after carbon-ion radiotherapy.
• Analyzed local control rates in patients with and without pre-therapy hypoxia.
• Explored the prognostic value of combining 18F-FMISO and 18F-FDG PET/CT imaging.
• Significant decrease in tumor hypoxia was observed after carbon-ion radiotherapy.
• Local control rates were comparable regardless of pre-treatment hypoxia status.
• Post-therapy hypoxia clearance showed a non-significant trend towards improved local control.