What question did this study set out to answer?

This research aims to investigate the effects of carbon-ion radiotherapy on tumor hypoxia in patients with locally advanced non-small cell lung cancer.

January 22, 2026European Journal of Nuclear Medicine and Molecular Imaging0 citationsOpen Access

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Impact of carbon-ion radiotherapy on tumor hypoxia detected by 18F-FMISO PET/CT in locally advanced non-small cell lung cancer

JCJ ChenFudan University Shanghai Cancer Center JCJingYi ChengFudan University Shanghai Cancer Center NMNingyi MaFudan University Shanghai Cancer Center

Key Points

This research aims to investigate the effects of carbon-ion radiotherapy on tumor hypoxia in patients with locally advanced non-small cell lung cancer.
Utilized 18F-FMISO PET/CT to measure tumor hypoxia before and after carbon-ion radiotherapy.
Analyzed local control rates in patients with and without pre-therapy hypoxia.
Explored the prognostic value of combining 18F-FMISO and 18F-FDG PET/CT imaging.
Significant decrease in tumor hypoxia was observed after carbon-ion radiotherapy.
Local control rates were comparable regardless of pre-treatment hypoxia status.
Post-therapy hypoxia clearance showed a non-significant trend towards improved local control.

Abstract

Tumor hypoxia detected by 18F-FMISO PET/CT was significantly decreased after CIRT in patients with LA-NSCLC. Similar LC was achieved in patients with or without pre-CIRT hypoxia, while post-CIRT hypoxia clearance resulted in a non-significant trend toward improved LC. Combining 18F-FMISO and 18F-FDG PET/CT might provide enhanced prognostic value. Further investigation is warranted to explore individualized CIRT dose painting strategies guided by multi-tracer PET/CT imaging.

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Cite This Study

Chen et al. (Tue,) studied this question.

synapsesocial.com/papers/6971bea8642b1836717e357b https://doi.org/https://doi.org/10.1007/s00259-025-07702-4

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