Impact of carbon-ion radiotherapy on tumor hypoxia detected by 18F-FMISO PET/CT in locally advanced non-small cell lung cancer

J Chen; JingYi Cheng; Ningyi Ma; Jingfang Mao; K. Wu; G. Jiang

doi:10.1007/s00259-025-07702-4

January 20, 2026European Journal of Nuclear Medicine and Molecular ImagingOpen Access

Impact of carbon-ion radiotherapy on tumor hypoxia detected by 18F-FMISO PET/CT in locally advanced non-small cell lung cancer

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Key Points

This research aims to investigate the effects of carbon-ion radiotherapy on tumor hypoxia in patients with locally advanced non-small cell lung cancer.
Utilized 18F-FMISO PET/CT to measure tumor hypoxia before and after carbon-ion radiotherapy.
Analyzed local control rates in patients with and without pre-therapy hypoxia.
Explored the prognostic value of combining 18F-FMISO and 18F-FDG PET/CT imaging.
Significant decrease in tumor hypoxia was observed after carbon-ion radiotherapy.
Local control rates were comparable regardless of pre-treatment hypoxia status.
Post-therapy hypoxia clearance showed a non-significant trend towards improved local control.

Implication

Study shows decreased tumor hypoxia in lung cancer following carbon-ion radiotherapy, suggesting potential treatment improvements.

Abstract

Tumor hypoxia detected by ¹⁸F-FMISO PET/CT was significantly decreased after CIRT in patients with LA-NSCLC. Similar LC was achieved in patients with or without pre-CIRT hypoxia, while post-CIRT hypoxia clearance resulted in a non-significant trend toward improved LC. Combining ¹⁸F-FMISO and ¹⁸F-FDG PET/CT might provide enhanced prognostic value. Further investigation is warranted to explore individualized CIRT dose painting strategies guided by multi-tracer PET/CT imaging.

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Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6971bea8642b1836717e357b https://doi.org/10.1007/s00259-025-07702-4

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Impact of carbon-ion radiotherapy on tumor hypoxia detected by 18F-FMISO PET/CT in locally advanced non-small cell lung cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Impact of carbon-ion radiotherapy on tumor hypoxia detected by 18F-FMISO PET/CT in locally advanced non-small cell lung cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

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