Impact of Protein Corona on Magnetic Particle Spectroscopy-Based Bioassays

Key Points

• The research aims to explore how protein corona influences the behavior of functionalized magnetic nanoparticles in bioassays.
• Utilized magnetic nanoparticles and functionalized them with specific ligands.
• Examined the aggregation of these nanoparticles in the presence of targeted biomolecules.
• Performed assays to evaluate the impact of protein corona on bioassay outcomes.
• Detected changes in the aggregation behavior of functionalized magnetic nanoparticles with varying protein concentrations.
• Observed differences in assay sensitivity and specificity due to protein interactions.
• Found that protein corona can lead to significant variations in bioassay results.