RNA nanostructures based on three-letter coding with non-canonical base pairs

Key Points

• The study aims to explore synthetic RNA nanostructures incorporating non-canonical base pairs using a three-letter coding system.
• Developed RNA constructs based on A, G, and C nucleotides.
• Utilized non-canonical A·C base pairing in design.
• Analyzed the structural integrity and functionality of the synthesized nanostructures.
• Demonstrated successful incorporation of non-canonical base pairs in RNA constructs.
• Achieved stable RNA nanostructures with enhanced functional capabilities.
• Highlighted potential for expanding the genetic code in synthetic biology.