Genetics identifies obesity as a shared risk factor for co-occurring multiple long-term conditions

Key Points

• The research aims to quantify how obesity contributes to the occurrence of multiple long-term conditions through genetic analysis.
• Implemented a genetics-centered approach to assess the role of obesity in multi-morbidity.
• Utilized a method for calculating full and partial genetic correlations.
• Published the method as an R package named partialLDSC.
• Obesity was identified as a significant shared risk factor for various long-term conditions.
• Quantitative measures of genetic contribution to multi-morbidity were established.