What question did this study set out to answer?

To evaluate the effects of cynaropicrin on the migratory behavior of triple-negative breast cancer cells and elucidate the underlying mechanisms.

February 8, 20260 citations

The effect of cynaropicrin, a sesquiterpene lactone, on the migratory properties of triple-negative breast cancer cells and the underlying mechanisms.

MAMauricio AmaralNational University of East Timor HHHamad Ali HamadUniversiti Putra Malaysia SMSoumya V MenonJain University

Key Points

To evaluate the effects of cynaropicrin on the migratory behavior of triple-negative breast cancer cells and elucidate the underlying mechanisms.
Conducted experiments on triple-negative breast cancer cell lines.
Analyzed the effect of cynaropicrin on epithelial-mesenchymal transition (EMT).
Measured levels of pro-angiogenic factors such as VEGFA.
Cynaropicrin was found to inhibit migration of triple-negative breast cancer cells.
Cynaropicrin reduced the expression of EMT markers.
Decreased levels of VEGFA were observed, supporting anti-angiogenic properties.

Abstract

The present findings indicated the anti-metastatic capacity of cynaropicrin against TNBC by a mechanism that implicated the inhibition of the EMT and pro-angiogenic factor VEGFA. These outcomes suggest cynaropicrin as an anti-metastatic and anti-angiogenic sesquiterpene lactone against TNBC.

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