Myo9b gene polymorphisms are variably associated with increased susceptibility to autoimmune diseases and cancer progression, notably linked to intestinal barrier dysfunction and metastasis mechanisms.
Myosin IXb (Myo9b) is a single-headed motor protein in the myosin superfamily. It contains a unique Rho guanosine triphosphatase-activating protein domain, which enables it to regulate cytoskeletal dynamics and cell migration. Most studies on Myo9b are focused on epithelial repair, intestinal barrier function, and immune cell motility; however, its roles in immune regulation, inflammatory responses, tumorigenesis, and various autoimmune diseases have garnered notable attention in recent years. This study comprehensively reviews the structural characteristics, regulatory mechanisms, and biological functions of Myo9b, along with emphasizing its crucial roles in various pathological conditions and its potential as a therapeutic target.
Dong et al. (Fri,) conducted a review in Patients with various autoimmune diseases, inflammatory bowel disease, celiac disease, type 1 diabetes, systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, and various cancers including lung, breast, prostate, and gastrointestinal cancers. Myosin IXb gene polymorphisms or Myosin IXb expression modulation vs. Controls or wild-type conditions was evaluated on Association of Myosin IXb polymorphisms or expression with disease susceptibility or progression. Myo9b gene polymorphisms are variably associated with increased susceptibility to autoimmune diseases and cancer progression, notably linked to intestinal barrier dysfunction and metastasis mechanisms.