What question did this study set out to answer?

This research aims to provide expert recommendations for managing side effects in children with low-grade glioma receiving MAPK inhibitors.

February 9, 2026Neuro-Oncology Practice1 citationsOpen Access

Management of adverse events in patients with pediatric low-grade glioma treated with MAPK-directed therapies: Delphi consensus recommendations and unmet needs

DHDarren Hargrave DBDaniel C. Bowers SGStewart Goldman

Key Points

This research aims to provide expert recommendations for managing side effects in children with low-grade glioma receiving MAPK inhibitors.
Consensus recommendations developed by an expert group
Focus on managing skin-related adverse events
Strategies include preemptive care and multi-disciplinary collaboration
Skin issues are the most frequent side effects observed.
Proactive measures like moisturizing and sunscreen application can prevent skin problems.
A multi-disciplinary approach is emphasized for optimal care.

Abstract

Lay Summary Children with low-grade glioma (a type of brain cancer) are often treated with MAPK inhibitors (MAPKi). These drugs target the cancer, but have side effects. An expert group has developed guidance on how to manage these side effects, so that children can feel better while on treatment. Skin problems are the most common side effects. It is important to take care of skin before problems show, e.g., by moisturizing and using sunscreen. Additional skin treatments may be needed. A multi-disciplinary approach is needed for children to have the best care while being treated with MAPKi.

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Cite This Study

Hargrave et al. (Mon,) studied this question.

synapsesocial.com/papers/69897a35f0ec2af6756e896d https://doi.org/https://doi.org/10.1093/nop/npag006

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