LncRNA AK154753 mediates the development of acute kidney ischemia reperfusion injury via the miR-345-3p/Bak and miR-708-5p/Bim pathways.

Key Points

• The aim is to explore the role of lncRNA AK154753 in acute kidney ischemia reperfusion injury (IRI).
• Examined lncRNA expression in acute renal IRI models.
• Assessed the impact of AK154753 on apoptosis through miRNA interactions.
• Analyzed the expression levels of Bak and Bim proteins.
• AK154753 is significantly upregulated in acute renal IRI.
• Inhibition of miR-345-3p and miR-708-5p leads to increased Bak and Bim expression.
• Enhanced apoptosis occurs in acute renal IRI due to the action of AK154753.