The research aims to explore how mitophagy affects the osteogenic differentiation of periodontal ligament stem cells (PDLSCs) under tension during ageing.
Examined the role of mitophagy in PDLSCs under tension conditions.
Analyzed osteogenic differentiation markers in PDLSCs.
Investigated age-related differences in mitophagy activity in PDLSCs.
Mitophagy enhances osteogenic differentiation in PDLSCs when subjected to tension.
Age affects the efficiency of mitophagy in PDLSCs, suggesting changes in differentiation ability over time.
Abstract
Mitophagy is associated with osteogenic activity induced by tension force in PDLSCs and may play a substantial role in regulating age-related changes in the OTM process.