What question did this study set out to answer?

February 11, 2026Asian Pacific Journal of Cancer Prevention0 citationsOpen Access

Crosstalk between ZEB1 expression and CD163+ Tumor-Associated Macrophages in Muscle-Invasive Urothelial Carcinoma

AAAhmed M. Al‐HakamiKing Khalid University SASara Salah Abdel-HakeemAssiut University FKFatma M M KamalAssiut University

Key Points

This research investigates the relationship between ZEB1 expression and CD163+ tumor-associated macrophages in muscle-invasive urothelial carcinoma.
Analyzed ZEB1 expression levels in muscle-invasive urothelial carcinoma samples.
Assessed the density of CD163+ tumor-associated macrophages (TAMs).
Correlated ZEB1 expression with clinical prognosis.
Elevated ZEB1 expression is linked to increased CD163+ TAM density.
Higher levels of ZEB1 expression correlate with poor clinical outcomes.
ZEB1 shows potential as a biomarker for prognosis in bladder cancer.

Abstract

Elevated ZEB1 expression is strongly associated with poor prognosis in BC and closely correlated with an increased density of CD163+TAMs, further contributing to adverse outcomes. These findings highlight the potential of ZEB1 as a prognostic biomarker and underscore the therapeutic relevance of targeting TAMs in the management of BC.

问 AI

Bookmark

View Full Paper

Cite This Study

Al‐Hakami et al. (Sun,) studied this question.

synapsesocial.com/papers/698c1c73267fb587c655ef94 https://doi.org/https://doi.org/10.31557/apjcp.2026.27.2.499

问 AI

Bookmark

View Full Paper