Association between anti-tumor necrosis factor alpha exposure and new-onset autoimmune diseases in inflammatory bowel disease: a nationwide case-control study in Korea

Key Points

• The research aims to evaluate the connection between anti-TNF therapy and the development of new autoimmune diseases in individuals with inflammatory bowel disease.
• Nationwide case-control study conducted in Korea.
• Analysis of patients receiving anti-TNF therapy for inflammatory bowel disease.
• Assessment of incidence of new-onset autoimmune diseases such as psoriasis and ILD.
• Anti-TNF therapy is associated with a significant risk of new-onset autoimmune diseases.
• Psoriasis and interstitial lung disease are particularly common among these new cases.
• Prolonged and combined immunosuppressive therapies further increase the risks.