Environmental bisphenols hijack the Hmox1 and Cdh1 to trigger premature ovarian insufficiency: A multi-omics investigation

Key Points

• This research aims to evaluate how bisphenols affect ovarian function by targeting Hmox1 and Cdh1.
• Utilized a multi-omics approach to analyze biomarker activity
• Evaluated the modulation of apoptosis in ovarian cells
• Assessed the role of endocrine resistance in ovarian dysfunction
• Hmox1 and Cdh1 were identified as key biomarkers for bisphenol-induced ovarian issues
• Bisphenols significantly trigger pathways leading to premature ovarian insufficiency
• Potential therapeutic targets for managing toxin-related ovarian dysfunction were highlighted.