The study aims to evaluate the effects of N-acetylcystein in reducing vestibulotoxicity induced by gentamicin.
Used a guinea pig model for vestibulotoxicity via gentamicin administration.
Administered intratympanic N-acetylcystein as a potential protective agent.
Measured c-VEMP responses and assessed oxidative capacity in tissue and serum.
Gentamicin caused a significant loss in c-VEMP responses.
N-acetylcystein effectively reduced the loss of c-VEMP responses.
Oxidative capacity measurements confirmed the protective role of NAC at tissue and serum levels.
Abstract
Gentamicin induced loss in c-VEMP responses and NAC played an effective role in reducing this loss which were confirmed by oxidative capacity at tissue and serum level.