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February 13, 2026PharmacoEconomics - Open0 citationsOpen Access

Understanding the Humanistic Burden of Metabolic Dysfunction-Associated Steatohepatitis Liver Disease in the US Population: Age/Sex Stratified Analysis of Morbidity and Mortality

ABAndrew BriggsUniversity of East Anglia ZLZiyi LinLondon School of Hygiene & Tropical Medicine DADaniel AggioLloyd's

Key Points

The aim is to analyze the humanistic burden of metabolic dysfunction-associated steatohepatitis (MASH) by age and sex.
Age/sex stratified analysis of morbidity and mortality
Comparison of burden between males and females
Assessment of disease incidence related to obesity and diabetes
Mortality is a greater burden than morbidity for MASH
Higher burden observed in females compared to males due to longevity
Incidence of MASH is expected to increase with rising obesity and diabetes rates

Abstract

The analysis shows that mortality is a greater burden than morbidity for MASH, and that owing to the insidious nature of the disease, burden is likely to be concentrated in the seventh to eighth decade of life (60-79-year-olds). The burden for females is higher than for males, without differential incidence, owing to women's longevity. The incidence of MASH is expected to rise owing to the increasing prevalence of obesity and diabetes in the population.

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