Inflammatory cytokine profile in pregnant women colonized with group B streptococcus reveals IL-17A as a potential biomarker to identify at-risk newborns.

Key Points

• The research aims to identify inflammatory cytokines related to group B streptococcus colonization in pregnant women and their implications for newborns.
• Comparison of cytokine profiles between GBS-colonized and non-colonized mothers.
• Assessment of maternal IL-17A levels in relation to newborn GBS risk.
• Analysis of mother-newborn dyads to evaluate disease transmission dynamics.
• GBS-colonized mothers exhibit a higher inflammatory cytokine response.
• Maternal IL-17A levels correlate with increased risk of GBS transmission to newborns.
• IL-17A is identified as a significant biomarker for predicting neonatal invasive disease.