The study aims to identify molecular characteristics associated with severe bronchiolitis in children.
Used mucosal transcriptomics to assess gene expression profiles.
Focused on pediatric cases of RSV and all-cause bronchiolitis.
Analyzed the relationship between IL-36 secretion and immune response failure.
IL-36 secretion was prominently observed in severe cases.
Bronchiolitis cases showed an impaired interferon response.
Identified a link between IL-36 and life-threatening bronchiolitis.
Abstract
Mucosal transcriptomics identifies IL-36 secretion as a feature of life-threatening paediatric RSV and all-cause bronchiolitis associated with interferon response failure.