Prevalence of CSF HIV VIRAL Escape and Associations With Neurocognitive Outcomes Among HIV-Associated Meningitis Survivors: A Cohort Study

Key Points

• To evaluate the prevalence of CSF HIV viral escape and its associations with neurocognitive outcomes in survivors of HIV-associated meningitis.
• Prospective cohort study design
• Included 93 Ugandan adults post-meningitis
• Measured CSF HIV viral escape and neurocognitive function
• Analyzed associations with factors like antiretroviral therapy and CSF pleocytosis
• High prevalence of baseline secondary CSF HIV viral escape observed
• Associated with better neurocognitive outcomes at 3 months post-meningitis
• Patients with viral escape were more likely to be antiretroviral therapy–naïve
• Individuals exhibiting CSF pleocytosis showed higher rates of viral escape