What question did this study set out to answer?

This research aims to investigate the radioprotective effects of Agaricus bisporus polysaccharides on spermatogonial cells affected by X-ray exposure.

February 14, 2026Food & Function0 citations

Agaricus bisporus polysaccharide ABP alleviates X-ray-induced spermatogonial injury via the PI3K/AKT/mTOR pathway: toward a novel dietary radioprotectant

NJNan Jiang NFNa Feng YHYulin Huang

Key Points

This research aims to investigate the radioprotective effects of Agaricus bisporus polysaccharides on spermatogonial cells affected by X-ray exposure.
Use of Agaricus bisporus polysaccharides as an intervention.
Assessment of spermatogonial injury after X-ray exposure.
Analysis of the PI3K/AKT/mTOR signaling pathway for understanding mechanisms.
Agaricus bisporus polysaccharide significantly reduces spermatogonial injury after X-ray exposure.
Activation of the PI3K/AKT/mTOR pathway is linked to the protective effects observed.

Abstract

Polysaccharides from edible mushrooms are promising dietary ingredients for functional foods due to their potent antioxidant and cytoprotective activities.

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