Agaricus bisporus polysaccharide ABP alleviates X-ray-induced spermatogonial injury via the PI3K/AKT/mTOR pathway: toward a novel dietary radioprotectant | Synapse
February 14, 2026
Agaricus bisporus polysaccharide ABP alleviates X-ray-induced spermatogonial injury via the PI3K/AKT/mTOR pathway: toward a novel dietary radioprotectant
Key Points
This research aims to investigate the radioprotective effects of Agaricus bisporus polysaccharides on spermatogonial cells affected by X-ray exposure.
Use of Agaricus bisporus polysaccharides as an intervention.
Assessment of spermatogonial injury after X-ray exposure.
Analysis of the PI3K/AKT/mTOR signaling pathway for understanding mechanisms.
Agaricus bisporus polysaccharide significantly reduces spermatogonial injury after X-ray exposure.
Activation of the PI3K/AKT/mTOR pathway is linked to the protective effects observed.
Abstract
Polysaccharides from edible mushrooms are promising dietary ingredients for functional foods due to their potent antioxidant and cytoprotective activities.