To develop a mild, metal-free method for the regioselective reduction of 3-alkylidene oxindoles.
Utilized thiophenol as a mediator for reduction
Employed a thiol–ene-type Michael addition pathway
Focused on regioselectivity in product formation
Achieved successful reduction of 3-alkylidene oxindoles
Demonstrated chemoselectivity in the reaction
Reactions were conducted under mild conditions without metal catalysts
Abstract
Mild and metal-free thiophenol-mediated protocol for the regioselective reduction of 3-alkylidene oxindoles via a thiol–ene-type Michael addition pathway.