Thiophenol-mediated metal-free chemoselective conjugate reduction strategy for 3-alkylidene oxindoles

Baliram R. Patil; Chandrakant B. Nichinde; Amardipsing S. Girase; Suryakant S. Chaudhari; Anil K. Kinage

doi:10.1039/d5ra09175f

January 1, 2026RSC AdvancesOpen Access

Thiophenol-mediated metal-free chemoselective conjugate reduction strategy for 3-alkylidene oxindoles

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Key Points

To develop a mild, metal-free method for the regioselective reduction of 3-alkylidene oxindoles.
Utilized thiophenol as a mediator for reduction
Employed a thiol–ene-type Michael addition pathway
Focused on regioselectivity in product formation
Achieved successful reduction of 3-alkylidene oxindoles
Demonstrated chemoselectivity in the reaction
Reactions were conducted under mild conditions without metal catalysts

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Implication

Mild protocol facilitates conjugate reduction in 3-alkylidene oxindoles, suggesting a new metal-free approach.

Abstract

Mild and metal-free thiophenol-mediated protocol for the regioselective reduction of 3-alkylidene oxindoles via a thiol–ene-type Michael addition pathway.

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Cite This Study

Patil et al. (2026) studied this question.

synapsesocial.com/papers/699e9166f5123be5ed04ee56 https://doi.org/10.1039/d5ra09175f

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Thiophenol-mediated metal-free chemoselective conjugate reduction strategy for 3-alkylidene oxindoles

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Thiophenol-mediated metal-free chemoselective conjugate reduction strategy for 3-alkylidene oxindoles

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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