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May 24, 2026The Journal of Organic Chemistry

A Hydride-Free Approach to the Chemoselective Reduction of 3-Phenacylidene-2-oxindoles Using Thiourea Dioxide

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Authors

SGSivaparwathi GollaNSNeetika SinghNNNagaraju Naddi

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Overview

Randomized trial demonstrates effective reduction of C═C bonds in 3-phenacylidene-2-oxindoles, indicating a practical alternative for activated olefins.

Key Points

  • The aim is to develop a simple and effective method for the chemoselective reduction of 3-phenacylidene-2-oxindoles using thiourea dioxide.
  • Utilized thiourea dioxide as a hydride-free reducing agent under mild conditions.
  • Conducted the reduction of activated C═C bonds in various substituted substrates.
  • Assessed yields of the corresponding reduced products.
  • Achieved good to excellent yields of reduced products across a broad range of substrates.
  • Maintained high chemoselectivity without affecting sensitive functional groups.

Cite This Study

Golla et al. (2026) studied this question.

synapsesocial.com/papers/6a12955d48a0ea16656718cfhttps://doi.org/10.1021/acs.joc.6c00286
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