Feasibility Study of Decellularized Corneal Lenticule in a Porcine Model for Macular Hole Closure

Key Points

• This research aims to explore the use of decellularized corneal lenticules for closing full-thickness macular holes.
• Conducted a preclinical ex vivo study using porcine models.
• Implanted decellularized human corneal lenticules (hCLs).
• Utilized optical coherence tomography (OCT) for monitoring the setup.
• Decellularized hCLs successfully closed macular holes in the ex vivo model.
• Paves the way for future research on bioengineered hCLs for therapeutic uses.