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A pH-Stable Dynamic DNA Nanomachine with Controllable Conformational Switching | Synapse

February 26, 2026Nanoscale Advances1 citationsOpen Access

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A pH-Stable Dynamic DNA Nanomachine with Controllable Conformational Switching

LLLixuan LinChinese Academy of Sciences KLKaiyi LiangJiading District Central Hospital XGXiuli GaoChinese Academy of Sciences

Key Points

This research aims to address the stability and functionality of dynamic DNA nanomachines under varying physiological pH.
Systematic evaluation of a six-helix DNA nanomachine
Investigation of performance across different pH levels
Identified that physiological pH significantly affects stability
Demonstrated conformation changes enhance functional performance of the DNA nanomachine

Abstract

The heterogeneity of physiological pH poses a major challenge to the stability and function of dynamic DNA nanomachines. Here, we systematically evaluate the performance of a six-helix DNA nanomachine (6H-NNM)...

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Cite This Study

Lin et al. (Thu,) studied this question.

synapsesocial.com/papers/699f95ba1bc9fecf3dab3edd https://doi.org/https://doi.org/10.1039/d5na01166c