Bioactive cationic lipidated oligomers (CLOs) as antimicrobial materials: metabolomic insights into MRSA membrane disruption

Key Points

• The aim is to investigate how cationic lipidated oligomers affect MRSA membranes through metabolomic analysis.
• Used untargeted metabolomics to analyze MRSA membranes
• Examined the effects of two structurally distinct CLOs on lipid profiles
• Performed comparative analysis of membrane disruptions
• Distinct changes in MRSA membrane lipids were identified
• CLOs cause specific lipid disruptions indicative of membrane damage
• Differences in lipid disruption patterns between the two CLOs were observed