P2X7R deficiency alleviates cardiac senescence by enhancing mitophagy via the HuR/TRIM26/NR4A1 axis. | Synapse
February 28, 2026
P2X7R deficiency alleviates cardiac senescence by enhancing mitophagy via the HuR/TRIM26/NR4A1 axis.
Key Points
This research aims to explore how P2X7R deficiency affects cardiac ageing, focusing on the role of the HuR/TRIM26/NR4A1 axis.
Investigated the effects of P2X7R deficiency on cardiac tissues.
Analyzed mitophagy markers related to cellular aging.
Examined the HuR/TRIM26/NR4A1 signalling pathway for its regulatory role.
P2X7R deficiency significantly enhances mitophagy in cardiac tissues.
Activation of the HuR/TRIM26/NR4A1 axis is identified as crucial in improving cardiac health.
Findings suggest a potential therapeutic target for cardiac ageing.
Abstract
Our findings provide valuable insights into the role of P2X7R in cardiac ageing and identify the HuR/TRIM26/NR4A1 axis as a key signalling pathway through which P2X7R regulates cardiac ageing.