Empowering exhausted T cells of Glioblastoma patients by Neurotransmitters and Neuropeptides: decreasing immune checkpoint inhibitors, and increasing CD3zeta, proliferation and Glioblastoma arrest

Key Points

• Increased proliferation and CD3zeta among T cells was observed, emphasizing the role of neurotransmitters and neuropeptides.
• The study highlights a significant decrease in immune checkpoint inhibitors, potentially enhancing T cell activity.
• Observational analysis examined T cells' responses in glioblastoma patients with varying neurotransmitter and neuropeptide levels.
• Findings indicate a need for further investigation into neuropeptide effects on tumor arrest and T cell function.