Quantitative prediction of human metabolites formed from the oxidation of the alcohol group of the glucokinase activator, TMG-123, using chimeric mice with humanized livers

Key Points

• Metabolites generated from TMG-123 oxidation were quantitatively predicted, providing new insights into metabolic processes.
• Key findings indicate the formation of several specific metabolites resulting from the oxidation of the alcohol group.
• Analysis using chimeric mice with humanized livers modeled human metabolic pathways effectively, enhancing relevance.
• Study highlights the potential for improved understanding of drug metabolism and therapeutic implications in humans.