March 3, 2026Journal of Integrative Medicine0 citationsOpen Access

Honokiol protects against acute pancreatitis by activating SIRT3 to restore mitochondrial oxidative phosphorylation and alleviate hyperacetylation

YMYi-Fan MiaoChengdu University of Traditional Chinese Medicine JYJiaqi YaoSichuan University YPYang PengChengdu University of Traditional Chinese Medicine

Key Points

Honokiol restores mitochondrial oxidative phosphorylation, enhancing cellular energy production.
SIRT3 activation leads to the deacetylation of CYC1, a key component in mitochondrial function.
Analysis demonstrates that increased SIRT3 activity alleviates hyperacetylation during acute pancreatitis.
Implications highlight the potential of honokiol as a therapeutic agent in managing pancreatic inflammatory conditions.

Abstract

Honokiol activates SIRT3 and promotes deacetylation of the respiratory complex Ⅲ subunit CYC1, contributing to OXPHOS restoration and mitochondrial protection in AP. These findings suggest a previously unrecognized SIRT3-CYC1 signaling axis underlying honokiol's mitochondrial protective effects in AP. Please cite this article as: Miao YF, Yao JQ, Peng Y, Bai D, Fan SH, Li HY, Jin W, Lu Y. Honokiol protects against acute pancreatitis by activating SIRT3 to restore mitochondrial oxidative phosphorylation and alleviate hyperacetylation. J Integr Med. 2026; Epub ahead of print.

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