Primary Amoebic Meningoencephalitis caused by Complement C2 Deficiency | Synapse
March 3, 2026Open Access
Primary Amoebic Meningoencephalitis caused by Complement C2 Deficiency
Key Points
PAM can be caused by complement C2 deficiency, with significant clinical implications for immune health.
The study identifies a specific immunological error related to the complement system that increases susceptibility.
Understanding this connection helps to clarify the role of immune pathways in fighting Naegleria fowleri infections.
Further research is needed to explore additional genetic factors contributing to similar immune deficiencies.
Abstract
Our study demonstrates that PAM can be caused by a monogenic inborn error of immunity (IEI) and that the complement system is critical for human immunity against Naegleria fowleri.