In healthy adults, a modified RNA vs. inactivated influenza vaccine reduced laboratory-confirmed influenza-like illness at ≥14 d

Key Points

• The aim is to compare the effectiveness of a modified RNA vaccine versus an inactivated influenza vaccine in reducing influenza-like illness.
• Comparison of modified RNA and inactivated influenza vaccines
• Involvement of healthy adult participants
• Observation of laboratory-confirmed influenza-like illnesses
• Follow-up period of ≥14 days post-vaccination
• The modified RNA vaccine significantly reduced occurrences of influenza-like illness compared to the inactivated vaccine
• Laboratory-confirmed cases were lower among those receiving the modified RNA vaccine
• Improvements were observed at least 14 days post-vaccination