Vitamin D inhibits the development of colorectal cancer cells by regulating the gut microbiota and immune microenvironment using JAKSTAT signaling pathway.

Key Points

• The aim is to explore how vitamin D influences colorectal cancer cell development through gut microbiota and immune responses.
• Examined the effect of vitamin D on the JAK-STAT pathway activation.
• Analyzed gut microbiota composition and butyrate metabolism.
• Assessed macrophage polarization in response to vitamin D treatment.
• Vitamin D reduced the activation of the JAK-STAT pathway.
• Restoration of butyrate metabolism was observed.
• Macrophage polarization was rebalanced, indicating improved immune response.