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March 6, 2026Redox BiologyOpen Access

A Clinical Decision Framework for Redox-Adapted, EMT-High Cancers: From Ferroptosis Resistance to Precision Therapeutic Stratification

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Authors

MPMoon Nyeo ParkECEun‐Hae ChoSPSohyun Park

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Overview

Framework introduces a decision-oriented approach for therapeutic stratification in redox-adapted cancers, indicating practical implications.

Key Points

  • The research aims to develop a clinical decision framework that incorporates redox and EMT states for personalized cancer therapy.
  • Proposed a state-based framework translating adaptive tumor states into clinical decision rules.
  • Synthesize mechanistic and translational evidence of ferroptosis and antioxidant buffering.
  • Delineated redox-EMT tumor states for patient stratification and treatment planning.
  • Outlined a biomarker-guided strategy for dynamic monitoring of redox states using tissue and liquid biopsies.
  • Identified discrete tumor states from redox-low to redox-locked environments with ferroptosis resistance.
  • Highlighted NRF2's role in antifungal defense affecting treatment responsiveness.
  • Demonstrated that adaption strategies can supersede traditional oncogene dependency in specific patient populations.
  • Developed actionable clinical decision rules that integrate multiple biomarkers for targeted therapy selection.

Cite This Study

Park et al. (2026) studied this question.

synapsesocial.com/papers/69aa70c8531e4c4a9ff5ad98https://doi.org/10.1016/j.redox.2026.104111
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reactive oxygen species (ROS) in cancer: from redox signaling and metabolic plasticity to therapeutic vulnerabilities2026
  2. 2Ferroptosis Resistance: Redundant Antioxidant Networks Are a Barrier to Cancer Therapy2026
  3. 3Unlocking the ferroptotic window: Lipidomic rewiring and metabolic addiction in EMT-driven breast cancer resistance2026
  4. 4Oxidative and Antioxidant Systems in Ferroptosis of Cancer: Mechanisms, Regulations, and Therapeutic Targeting2026
  5. 5Genetic mutations governing ferroptosis sensitivity and resistance: a precision approach to cancer therapy2026 · 1 citations